Opioid crisis response encompasses multi-level government efforts to address the devastating impact of opioid addiction and overdose deaths across Canada. While healthcare and addiction services are primarily provincial responsibility, municipalities are on the front lines with emergency services responding to overdoses, police encountering addiction-related crime, and communities facing social impacts. Municipal responses include supporting supervised consumption sites, distributing naloxone (overdose-reversing medication), collaborating with health authorities on treatment access, and addressing homelessness connected to addiction. Effective response requires coordination across municipal emergency services, provincial health systems, federal drug policy, and community organizations.